Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties
2019
Autori
Vlaisavljević, SanjaJelaca, Sanja
Zengin, Gokhan
Mimica-Dukić, Neda
Berezni, Sanja
Miljić, Milorad
Dajić-Stevanović, Zora
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical app...lications.
Izvor:
RSC Advances, 2019, 9, 64, 37474-37483Izdavač:
- Royal Soc Chemistry, Cambridge
Finansiranje / projekti:
- Biološki aktivni prirodni proizvodi kao potencijalni izvori novih lekova i dijetetskih suplemenata (RS-MESTD-Basic Research (BR or ON)-172058)
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
DOI: 10.1039/c9ra08231j
ISSN: 2046-2069
WoS: 000501620400040
Scopus: 2-s2.0-85075594901
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Vlaisavljević, Sanja AU - Jelaca, Sanja AU - Zengin, Gokhan AU - Mimica-Dukić, Neda AU - Berezni, Sanja AU - Miljić, Milorad AU - Dajić-Stevanović, Zora PY - 2019 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5000 AB - The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications. PB - Royal Soc Chemistry, Cambridge T2 - RSC Advances T1 - Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties EP - 37483 IS - 64 SP - 37474 VL - 9 DO - 10.1039/c9ra08231j ER -
@article{ author = "Vlaisavljević, Sanja and Jelaca, Sanja and Zengin, Gokhan and Mimica-Dukić, Neda and Berezni, Sanja and Miljić, Milorad and Dajić-Stevanović, Zora", year = "2019", abstract = "The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.", publisher = "Royal Soc Chemistry, Cambridge", journal = "RSC Advances", title = "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties", pages = "37483-37474", number = "64", volume = "9", doi = "10.1039/c9ra08231j" }
Vlaisavljević, S., Jelaca, S., Zengin, G., Mimica-Dukić, N., Berezni, S., Miljić, M.,& Dajić-Stevanović, Z.. (2019). Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances Royal Soc Chemistry, Cambridge., 9(64), 37474-37483. https://doi.org/10.1039/c9ra08231j
Vlaisavljević S, Jelaca S, Zengin G, Mimica-Dukić N, Berezni S, Miljić M, Dajić-Stevanović Z. Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances. 2019;9(64):37474-37483. doi:10.1039/c9ra08231j .
Vlaisavljević, Sanja, Jelaca, Sanja, Zengin, Gokhan, Mimica-Dukić, Neda, Berezni, Sanja, Miljić, Milorad, Dajić-Stevanović, Zora, "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties" in RSC Advances, 9, no. 64 (2019):37474-37483, https://doi.org/10.1039/c9ra08231j . .