Приказ основних података о документу

dc.creatorBjelogrlić, Snežana
dc.creatorTodorović, Tamara R.
dc.creatorKojić, Milan
dc.creatorSencanski, Milan
dc.creatorNikolić, Milan
dc.creatorVisnjevac, Aleksandar
dc.creatorAraskov, Jovana
dc.creatorMiljković, Marija
dc.creatorMuller, Christian D.
dc.creatorFilipović, Nenad
dc.date.accessioned2020-12-17T22:29:07Z
dc.date.available2020-12-17T22:29:07Z
dc.date.issued2019
dc.identifier.issn0162-0134
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/4916
dc.description.abstractAnticancer activity of Pd complexes 1-5 with bidentate N-heteroaromatic hydrazone ligands was investigated on human acute monocytic leukemia (THP-1; cells in a suspension) and human mammary adenocarcinoma (MCF-7; two-dimensional layer and three-dimensional spheroid tumor model) cell lines. For the Pd(II) complexes with condensation products of ethyl hydrazainoacetate and quinoline-8-carboxaldehyde (complex 1) and 2-for-mylpyridine (complex 3), for which apoptosis was determined as a mechanism of anticancer activity, further investigation revealed that they arrest the cell cycle in G0/G1 phase, induce generation of reactive oxygen species and inhibit Topoisomerase I in vitro. In silico studies corroborate experimental findings that these complexes show topoisomerase inhibition activity in the micromolar range and indicate binding to a DNA's minor groove as another potential target. Based on the results obtained by circular dichroism and fluorescence spectroscopy measurements, the most active complexes are suitable to be delivered to a blood stream via human serum albumin.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationCOSTEuropean Cooperation in Science and Technology (COST) [CA15135, CA16119]
dc.rightsrestrictedAccess
dc.sourceJournal of Inorganic Biochemistry
dc.subjectPd(II) complexesen
dc.subjectHydrazonesen
dc.subjectApoptosisen
dc.subjectTopoisomerase I inhibitionen
dc.subjectDNA interactionsen
dc.subjectHSA interactionsen
dc.titlePd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identificationen
dc.typearticle
dc.rights.licenseARR
dc.citation.other199: -
dc.citation.rankM21
dc.citation.volume199
dc.identifier.doi10.1016/j.jinorgbio.2019.110758
dc.identifier.scopus2-s2.0-85068530825
dc.identifier.pmid31299379
dc.identifier.wos000488146900009
dc.type.versionpublishedVersion


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Приказ основних података о документу