alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives
2017
Autori
Popović-Djordjević, JelenaJevtić, Ivana I.
Grozdanić, Nada
Segan, Sandra
Zlatović, Mario
Ivanović, Milovan D.
Stanojković, Tatjana P.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study. All examined compounds showed higher inhibitory activity (IC50) against alpha-Gls compared to standard antidiabetic drug acarbose. The most potent was benzyl (3,4,5-trimethoxyphenyl) carbamate (12) with IC50 = 49.85 +/- 0.10 mu M. In vitro cytotoxicity of the investigated compounds was tested on three human cancer cell lines HeLa, A549 and MDA-MB-453 using MTT assay. The best antitumour activity was achieved with compound 2 (trans-5-phenethyl-1-phenylhexahydro-1H-imidazo[4,5-c] pyridin-2(3H)-one) against MDA-MB-453 human breast cancer cell line (IC50 = 83.41 +/- 1.60 mu M). Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs. The PLS model of preliminary QSAR study indicated that, in planing the future synthesis of more potent compounds,... the newly designed should have the substituents capable of polar interactions with receptor sites in various positions, while avoiding the increase of their lipophilicity.
Ključne reči:
alpha-Glucosidase inhibitors / carbamates / cyclic ureas / cytotoxicity / QSARIzvor:
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32, 1, 298-303Izdavač:
- Taylor & Francis Ltd, Abingdon
Finansiranje / projekti:
- Sinteza aminohinolina i njihovih derivata kao antimalarika i inhibitora botulinum neurotoksina A (RS-MESTD-Basic Research (BR or ON)-172008)
- Proučavanje odnosa strukture i aktivnosti novosintetisanih biološki aktivnih supstanci (RS-MESTD-Basic Research (BR or ON)-172032)
- Interakcije prirodnih proizvoda, njihovih derivata i kompleksnih jedinjenja sa proteinima i nukleinskim kiselinama (RS-MESTD-Basic Research (BR or ON)-172055)
- Modifikatori biološkog odgovora u fiziološkim i patološkim stanjima (RS-MESTD-Basic Research (BR or ON)-175011)
DOI: 10.1080/14756366.2016.1250754
ISSN: 1475-6366
PubMed: 28100083
WoS: 000392591100024
Scopus: 2-s2.0-85013757766
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Popović-Djordjević, Jelena AU - Jevtić, Ivana I. AU - Grozdanić, Nada AU - Segan, Sandra AU - Zlatović, Mario AU - Ivanović, Milovan D. AU - Stanojković, Tatjana P. PY - 2017 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4378 AB - The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study. All examined compounds showed higher inhibitory activity (IC50) against alpha-Gls compared to standard antidiabetic drug acarbose. The most potent was benzyl (3,4,5-trimethoxyphenyl) carbamate (12) with IC50 = 49.85 +/- 0.10 mu M. In vitro cytotoxicity of the investigated compounds was tested on three human cancer cell lines HeLa, A549 and MDA-MB-453 using MTT assay. The best antitumour activity was achieved with compound 2 (trans-5-phenethyl-1-phenylhexahydro-1H-imidazo[4,5-c] pyridin-2(3H)-one) against MDA-MB-453 human breast cancer cell line (IC50 = 83.41 +/- 1.60 mu M). Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs. The PLS model of preliminary QSAR study indicated that, in planing the future synthesis of more potent compounds, the newly designed should have the substituents capable of polar interactions with receptor sites in various positions, while avoiding the increase of their lipophilicity. PB - Taylor & Francis Ltd, Abingdon T2 - Journal of Enzyme Inhibition and Medicinal Chemistry T1 - alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives EP - 303 IS - 1 SP - 298 VL - 32 DO - 10.1080/14756366.2016.1250754 ER -
@article{ author = "Popović-Djordjević, Jelena and Jevtić, Ivana I. and Grozdanić, Nada and Segan, Sandra and Zlatović, Mario and Ivanović, Milovan D. and Stanojković, Tatjana P.", year = "2017", abstract = "The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study. All examined compounds showed higher inhibitory activity (IC50) against alpha-Gls compared to standard antidiabetic drug acarbose. The most potent was benzyl (3,4,5-trimethoxyphenyl) carbamate (12) with IC50 = 49.85 +/- 0.10 mu M. In vitro cytotoxicity of the investigated compounds was tested on three human cancer cell lines HeLa, A549 and MDA-MB-453 using MTT assay. The best antitumour activity was achieved with compound 2 (trans-5-phenethyl-1-phenylhexahydro-1H-imidazo[4,5-c] pyridin-2(3H)-one) against MDA-MB-453 human breast cancer cell line (IC50 = 83.41 +/- 1.60 mu M). Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs. The PLS model of preliminary QSAR study indicated that, in planing the future synthesis of more potent compounds, the newly designed should have the substituents capable of polar interactions with receptor sites in various positions, while avoiding the increase of their lipophilicity.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Journal of Enzyme Inhibition and Medicinal Chemistry", title = "alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives", pages = "303-298", number = "1", volume = "32", doi = "10.1080/14756366.2016.1250754" }
Popović-Djordjević, J., Jevtić, I. I., Grozdanić, N., Segan, S., Zlatović, M., Ivanović, M. D.,& Stanojković, T. P.. (2017). alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives. in Journal of Enzyme Inhibition and Medicinal Chemistry Taylor & Francis Ltd, Abingdon., 32(1), 298-303. https://doi.org/10.1080/14756366.2016.1250754
Popović-Djordjević J, Jevtić II, Grozdanić N, Segan S, Zlatović M, Ivanović MD, Stanojković TP. alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):298-303. doi:10.1080/14756366.2016.1250754 .
Popović-Djordjević, Jelena, Jevtić, Ivana I., Grozdanić, Nada, Segan, Sandra, Zlatović, Mario, Ivanović, Milovan D., Stanojković, Tatjana P., "alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):298-303, https://doi.org/10.1080/14756366.2016.1250754 . .