Biointerface dynamics - Multi scale modeling considerations
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2015
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Metapodaci
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Irreversible nature of matrix structural changes around the immobilized cell aggregates caused by cell expansion is considered within the Ca-alginate microbeads. It is related to various effects: (1) cell-bulk surface effects (cell-polymer mechanical interactions) and cell surface-polymer surface effects (cell-polymer electrostatic interactions) at the bio-interface, (2) polymer-bulk volume effects (polymer-polymer mechanical and electrostatic interactions) within the perturbed boundary layers around the cell aggregates, (3) cumulative surface and volume effects within the parts of the microbead, and (4) macroscopic effects within the microbead as a whole based on multi scale modeling approaches. All modeling levels are discussed at two time scales i.e. long time scale (cell growth time) and short time scale (cell rearrangement time). Matrix structural changes results in the resistance stress generation which have the feedback impact on: (1) single and collective cell migrations, (2) c...ell deformation and orientation, (3) decrease of cell-to-cell separation distances, and (4) cell growth. Herein, an attempt is made to discuss and connect various multi scale modeling approaches on a range of time and space scales which have been proposed in the literature in order to shed further light to this complex course-consequence phenomenon which induces the anomalous nature of energy dissipation during the structural changes of cell aggregates and matrix quantified by the damping coefficients (the orders of the fractional derivatives). Deeper insight into the matrix partial disintegration within the boundary layers is useful for understanding and minimizing the polymer matrix resistance stress generation within the interface and on that base optimizing cell growth.
Ključne reči:
Ca-alginate microbeads / Hydrogel partial disintegration / Anomalous nature of energy dissipation / Resistance matrix stress / Mathematical modelingIzvor:
Colloids and Surfaces B-Biointerfaces, 2015, 132, 236-245Izdavač:
- Elsevier, Amsterdam
Finansiranje / projekti:
- Razvoj novih inkapsulacionih i enzimskih tehnologija za proizvodnju biokatalizatora i biološki aktivnih komponenata hrane u cilju povećanja njene konkurentnosti, kvaliteta i bezbednosti (RS-46010)
- Razvoj i primena novih i tradicionalnih tehnologija u proizvodnji konkurentnih prehrambenih proizvoda sa dodatom vrednošću za evropsko i svetsko tržište - Stvorimo bogatstvo iz bogatstva Srbije (RS-46001)
DOI: 10.1016/j.colsurfb.2015.05.013
ISSN: 0927-7765
PubMed: 26047886
WoS: 000358094000029
Scopus: 2-s2.0-84936774887
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Lević, Steva AU - Nedović, Viktor AU - Bugarski, Branko PY - 2015 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/3849 AB - Irreversible nature of matrix structural changes around the immobilized cell aggregates caused by cell expansion is considered within the Ca-alginate microbeads. It is related to various effects: (1) cell-bulk surface effects (cell-polymer mechanical interactions) and cell surface-polymer surface effects (cell-polymer electrostatic interactions) at the bio-interface, (2) polymer-bulk volume effects (polymer-polymer mechanical and electrostatic interactions) within the perturbed boundary layers around the cell aggregates, (3) cumulative surface and volume effects within the parts of the microbead, and (4) macroscopic effects within the microbead as a whole based on multi scale modeling approaches. All modeling levels are discussed at two time scales i.e. long time scale (cell growth time) and short time scale (cell rearrangement time). Matrix structural changes results in the resistance stress generation which have the feedback impact on: (1) single and collective cell migrations, (2) cell deformation and orientation, (3) decrease of cell-to-cell separation distances, and (4) cell growth. Herein, an attempt is made to discuss and connect various multi scale modeling approaches on a range of time and space scales which have been proposed in the literature in order to shed further light to this complex course-consequence phenomenon which induces the anomalous nature of energy dissipation during the structural changes of cell aggregates and matrix quantified by the damping coefficients (the orders of the fractional derivatives). Deeper insight into the matrix partial disintegration within the boundary layers is useful for understanding and minimizing the polymer matrix resistance stress generation within the interface and on that base optimizing cell growth. PB - Elsevier, Amsterdam T2 - Colloids and Surfaces B-Biointerfaces T1 - Biointerface dynamics - Multi scale modeling considerations EP - 245 SP - 236 VL - 132 DO - 10.1016/j.colsurfb.2015.05.013 ER -
@article{ author = "Pajić-Lijaković, Ivana and Lević, Steva and Nedović, Viktor and Bugarski, Branko", year = "2015", abstract = "Irreversible nature of matrix structural changes around the immobilized cell aggregates caused by cell expansion is considered within the Ca-alginate microbeads. It is related to various effects: (1) cell-bulk surface effects (cell-polymer mechanical interactions) and cell surface-polymer surface effects (cell-polymer electrostatic interactions) at the bio-interface, (2) polymer-bulk volume effects (polymer-polymer mechanical and electrostatic interactions) within the perturbed boundary layers around the cell aggregates, (3) cumulative surface and volume effects within the parts of the microbead, and (4) macroscopic effects within the microbead as a whole based on multi scale modeling approaches. All modeling levels are discussed at two time scales i.e. long time scale (cell growth time) and short time scale (cell rearrangement time). Matrix structural changes results in the resistance stress generation which have the feedback impact on: (1) single and collective cell migrations, (2) cell deformation and orientation, (3) decrease of cell-to-cell separation distances, and (4) cell growth. Herein, an attempt is made to discuss and connect various multi scale modeling approaches on a range of time and space scales which have been proposed in the literature in order to shed further light to this complex course-consequence phenomenon which induces the anomalous nature of energy dissipation during the structural changes of cell aggregates and matrix quantified by the damping coefficients (the orders of the fractional derivatives). Deeper insight into the matrix partial disintegration within the boundary layers is useful for understanding and minimizing the polymer matrix resistance stress generation within the interface and on that base optimizing cell growth.", publisher = "Elsevier, Amsterdam", journal = "Colloids and Surfaces B-Biointerfaces", title = "Biointerface dynamics - Multi scale modeling considerations", pages = "245-236", volume = "132", doi = "10.1016/j.colsurfb.2015.05.013" }
Pajić-Lijaković, I., Lević, S., Nedović, V.,& Bugarski, B.. (2015). Biointerface dynamics - Multi scale modeling considerations. in Colloids and Surfaces B-Biointerfaces Elsevier, Amsterdam., 132, 236-245. https://doi.org/10.1016/j.colsurfb.2015.05.013
Pajić-Lijaković I, Lević S, Nedović V, Bugarski B. Biointerface dynamics - Multi scale modeling considerations. in Colloids and Surfaces B-Biointerfaces. 2015;132:236-245. doi:10.1016/j.colsurfb.2015.05.013 .
Pajić-Lijaković, Ivana, Lević, Steva, Nedović, Viktor, Bugarski, Branko, "Biointerface dynamics - Multi scale modeling considerations" in Colloids and Surfaces B-Biointerfaces, 132 (2015):236-245, https://doi.org/10.1016/j.colsurfb.2015.05.013 . .