Imides from natural sources as pharmacological agents

Abstract

Heterocyclic systems containing nitrogen are widespread among alkaloids, having different pharmacological activities. Five and six membered cyclic imide derivatives are valuable group of bioactive compounds, that act as androgen receptor antagonists, anti-inflammatory, anxiolytics, antivirals, antibacterials, and tumor suppressing agents. Those compounds rarely occur in natural sources, but so far isolated ones exert widespread pharmacological activities, which makes them valuable as potential pharmacotherapeutics.

Heterociklični sistemi koji sadrže azot su veo- ma rasprostranjeni među alkaloidima i ispoljavaju različitu farmakološku aktivnost. Petočlani i šestočlani ciklični imidi su značajna bioaktivna jedinjenja koja deluju kao antagonisti androgenih receptora, antiinflamatorni agensi, anksiolitici, antivirotici, antibiotici i agensi koji sprečavaju razvoj različitih tumora. Iako se ova jedinjenja retko nalaze u prirodnim proizvodima, svi do sada izolovani imidi ispoljavaju farmakološku aktivnost, što ukazuje na njihov značaj kao potencijalnih farmakoterapeutika.